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Discovery explains why women face higher risk of Alzheimer’s and multiple sclerosis
New research by UCLA Health has identified a sex-chromosome linked gene that drives inflammation in the female brain, offering insight into why women are disproportionately affected by conditions such as Alzheimer's disease and multiple sclerosis as well as offering a potential target for intervention.
Nanotechnology breakthrough reverses Alzheimer’s disease in mice
A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer's disease in mice.
Study links high neuroinflammation in young people with Down Syndrome to Alzheimer's risk
Down syndrome is associated with accelerated aging. It is estimated that up to 90% of individuals with the condition develop Alzheimer's disease before the age of 70. A study by researchers at the University of São Paulo (USP) in Brazil identified high levels of neuroinflammation in young individuals with Down syndrome, an additional factor explaining the high prevalence of Alzheimer's disease in older people with the condition. The discovery paves the way for strategies to prevent and monitor the disease.
Why universal COVID-19 vaccine guidance offers stronger protection than high-risk-only policies
The US Scenario Modeling Hub’s nine-team ensemble projected COVID-19 hospitalizations and deaths for April 2024 to April 2025 under six policy and immune-escape scenarios. Burden was similar to the prior year, with universal vaccination recommendations averting more outcomes than high-risk-only guidance, especially for adults aged 65 years and older.
New research positions the placenta at the center of human neurodevelopment and evolution
In a Genomic Press Interview published today in Brain Medicine, Dr. Alex Tsompanidis highlights an exciting new idea that positions the placenta at the center of human neurodevelopment and evolution, challenging conventional wisdom about the origins of autism and human cognition.
Lymphatic vessels found to undergo dramatic changes during kidney transplant rejection
Scientists have uncovered how lymphatic vessels – the kidney's 'plumbing system' – undergo dramatic changes during chronic transplant rejection, becoming structurally disorganised and spreading to unusual parts of the kidney.
Children show high exposure to PFAS despite regulatory restrictions
These chemical compounds are highly stable and linger in the environment. Thanks to their water-, oil- and stain-repellent properties, they are widely found in everyday items, such as non-stick pans, waterproof clothing, food containers and fire-fighting foams.
Mentavi study validates first fully digital diagnostic pathway for adult ADHD
Mentavi Health announced that its landmark, real-world validation study of the Mentavi Diagnostic Evaluation has been published in the peer-reviewed Journal of Clinical Psychiatry (JCP), a widely read and respected journal.
Global climate warming fuels rising dengue burden across Asia and the Americas
Warmer weather across the globe is reshaping the landscape of human health. Case in point: dengue fever, a mosquito-borne disease once confined largely to the tropics which often brings flu-like symptoms and without proper medical care can escalate to severe bleeding, organ failure, and even death.
‘Rogue’ DNA rings identified as drivers of aggressive brain cancer
An international team of scientists has revealed how rogue rings of DNA that float outside of our chromosomes – known as extrachromosomal DNA, or ecDNA – can drive the growth of a large proportion of glioblastomas, the most common and aggressive adult brain cancer.
Innovative approach advances equity in health care AI
A team of researchers at the Icahn School of Medicine at Mount Sinai has developed a new method to identify and reduce biases in datasets used to train machine-learning algorithms-addressing a critical issue that can affect diagnostic accuracy and treatment decisions.
Study finds universal rise in cholesterol after menopause among Bolivian Tsimane women
Deep in the Bolivian Amazon exists a forager-horticultural community called the Tsimane. Researchers look to them for insights on how the human body functioned prior to modern technologies, as their lifestyles remain the closest to that of our ancestors.
Generative AI creates life-saving antibiotics from scratch
What if generative AI could design life-saving antibiotics, not just art and text? In a new Cell Biomaterials paper, Penn researchers introduce AMP-Diffusion, a generative AI tool used to create tens of thousands of new antimicrobial peptides (AMPs) - short strings of amino acids, the building blocks of proteins - with bacteria-killing potential.
Breakthrough reveals how viruses efficiently pack genetic material
Researchers at San Diego State University and Michigan State University are shedding new light on how viruses meticulously pack their genetic material - a breakthrough that could help researchers engineer antivirals and gene therapies.
Genetic evidence reveals global patterns of language change
Throughout human history, there have been many instances where two populations came into contact – especially in the past few thousand years because of large-scale migrations as a consequence of conquests, colonialization, and, more recently, globalization.