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Scientists open new atlas of genetic diversity with advanced sequencing
A global team mapped over 100,000 structural variants in human genomes by applying Oxford Nanopore long-read sequencing and a novel graph-based analytical approach to samples from 26 populations. The study reveals the extraordinary complexity and diversity of human DNA, providing an open-access atlas that will accelerate discoveries in genetic disease and human evolution.
Predicting measles vaccination coverage for targeted public health action
Knowing how many people are vaccinated against an existing or re-emerging threat is a key factor guiding public health decisions, but such information is often sparse or non-existent in many regions, according to researchers at Penn State.
What’s better for your gut: lean beef or chicken? Science weighs in
A crossover trial in healthy young adults found that both lean chicken and beef diets reduced gut microbial richness, but only chicken caused significant diversity loss. The study highlights that lean local beef may have a milder impact on the gut microbiome than chicken.
Review highlights the evolution of research related to implantable brain-computer interfaces
A review published in Advanced Science highlights the evolution of research related to implantable brain-computer interfaces (iBCIs), which decode brain signals that are then translated into commands for external devices to potentially benefit individuals with impairments such as loss of limb function or speech.
Insights into antibiotic resistance and virulence of Bordetella hinzii
Announcing a new article publication for Zoonoses journal. This study was aimed at analyzing the pathogenic characteristics of Bordetella hinzii (B. hinzii), and elucidating its antibiotic resistance mechanisms, virulence gene distribution, and vaccine development potential.
Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by targeting immunosuppressive dendritic cells
This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131-TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.
WHO maintains global emergency status for mpox following June 2025 IHR Emergency Committee meeting
The Director-General of the World Health Organization (WHO) is hereby transmitting the report of the fourth meeting of the International Health Regulations (2005) (IHR) Emergency Committee (Committee) regarding the upsurge of mpox 2024, held on Thursday, 5 June 2025, from 12:00 to 17:00 CEST.
AlphaFold2 enables large scale analysis of enzyme evolution
Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now succeeded in analyzing the laws of their evolution on a large scale.
Australian scientists use AI to create protein that kills superbugs
In the last year, there has been a surge in proteins developed by AI that will eventually be used in the treatment of everything from snakebites to cancer. What would normally take decades for a scientist to create – a custom-made protein for a particular disease – can now be done in seconds.
Understanding the human brain architecture through gene coexpression analysis
In a comprehensive Genomic Press Interview published in Brain Medicine, Dr. Michael C. Oldham shares his unconventional journey from advertising executive to computational neuroscientist and his groundbreaking contributions to understanding the human brain's cellular and molecular architecture through gene coexpression analysis.
Unlocking the brain’s language to fight Alzheimer’s
June is Alzheimer's and Brain Awareness Month. With an estimated 55 million people living with Alzheimer's Disease and other forms of dementia worldwide, advancing understanding of these complex diseases is critical to finding new treatments, and potentially, cures.
Smallest known protein-based enzyme HARP reveals dual role in tRNA processing
To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the right amino acids to ribosomes, the cell's protein-making factories.
New insights into nature's most remarkable innovation- the ability to sustain a successful pregnancy
An international research team led by scientists from the University of Vienna has uncovered new insights into how specialized cell types and communication networks at the interface between mother and fetus evolved over millions of years.
Study uncovers the molecular evolutionary strategies of the OxPhos system
Mitochondria are the body's "energy factories," and their proper function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system acts like a biochemical assembly line, transforming oxygen and nutrients into usable energy.
The clever ways Neanderthals got their fat long before modern humans
Neanderthals at Neumark-Nord, Germany, systematically transported and processed the bones of at least 172 large mammals to extract nutrient-rich "bone grease" nearly 125,000 years ago. This finding rewrites the timeline for large-scale fat processing, revealing unexpectedly complex resource strategies among Neanderthals.
Scientists trace leprosy’s roots in South America back 4,000 years
Researchers have recovered and sequenced Mycobacterium lepromatosis genomes from 4,000-year-old human remains in Chile, providing the first molecular evidence of ancient leprosy in the Americas. The findings reveal the deep evolutionary roots and complex spread of Hansen’s disease long before European contact.
Ancient DNA sheds light on the origins of leprosy in the Americas
Hansen's Disease, more commonly known as leprosy, is a chronic disease that can lead to physical impairment. Today it exists in over 100 countries, and while the infection is treatable, access to treatment varies widely with socioeconomic conditions.
Genetic bottlenecks limit the rise of pandemic cholera strains
A new study by the Genomics and Microbial Evolution Group at the Miguel Hernández University of Elche (UMH) together with the Department of Host-Microbe Interactions at St. Jude Children's Research Hospital in Memphis, USA, sheds light on one of the great enigmas of microbiology: why only certain strains of common bacteria become pandemic pathogens.
Study reveals how FOXA1 mutations drive prostate cancer and therapy resistance
A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene-commonly altered in prostate cancer-drive tumor initiation formation and therapeutic resistance.
Updated COVID-19 vaccines found effective against severe illness
A new multi-state study led by the Centers for Disease Control and Prevention's (CDC) VISION Network – including Regenstrief Institute – has provided the most comprehensive assessment to date of the effectiveness of 2023-2024 COVID-19 vaccines among adults in the U.S. during the XBB and JN.1 Omicron subvariant waves.
What happens when job candidates face AI instead of humans?
When people know they are being assessed by AI rather than humans, they tend to present themselves as more analytical and less intuitive or emotional. This “AI assessment effect” could shift hiring and admissions decisions, raising new questions for organizations relying on algorithmic evaluation.