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New insights into brain aging and Alzheimer's from non-human primates
A new review was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on October 29, 2024, Volume 16, Issue 20, titled, "Brain aging and Alzheimer's disease, a perspective from non-human primates."
New approach to stabilize RSV protein could lead to better vaccines
In most people, the lung-infecting pathogens known as respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) trigger mild cold-like symptoms. But in infants and seniors, these viruses can cause severe pneumonia and even death.
Malaria crystal structure offers clues for more effective medications
Prof. Leslie Leiserowitz first became intrigued by malaria when he was a young boy in South Africa. His father, who scouted the continent in search of wood for the family business, brought back not only tales of elephants and gorillas but also skin rashes and ringing in his ears, side effects of the quinine he took to prevent malaria.
Engineered virus-like particles evolve for superior gene delivery efficiency
Researchers developed a barcoded directed evolution system for engineered virus-like particles (eVLPs), creating a fifth-generation (v5) eVLP with enhanced production, transduction, and gene-editing efficiency. This system could pave the way for improved gene delivery vehicles in therapeutic applications.
Evo model set to transform synthetic biology and disease diagnosis
A new study presents "Evo" – a machine learning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Evo's ability to predict, generate, and engineer entire genomic sequences could change the way synthetic biology is done.
Seasonal influenza adapted and evolved during the COVID-19 pandemic
Although travel restrictions and social measures during the COVID-19 pandemic led to a dramatic global drop in seasonal influenza cases, certain influenza lineages in specific regions kept the virus circulating and evolving, according to a new study.
Targeted bacteriophages offer standardized and scalable GI therapy
In a new study, researchers at the University of Copenhagen have been cultivating 'good viruses' from feces. The goal is to replace fecal capsules now being used in so-called fecal transplants. Their new technique has shown potential in studies with mice and the hope is that it will improve this life-saving treatment through standardization and pave its way toward mainstream medicine.
Researchers link polyphosphate to protective role in neurodegenerative disease fibrils
Research led by the University of Michigan has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer’s, Parkinson’s and other neurodegenerative diseases
Dentists are pulling ‘healthy’ and treatable teeth to profit from implants, experts warn
Becky Carroll was missing a few teeth, and others were stained or crooked. Ashamed, she smiled with lips pressed closed. Her dentist offered to fix most of her teeth with root canals and crowns, Carroll said, but she was wary of traveling a long road of dental work.
Research uncovers potential role of polyphosphate in neurodegenerative diseases
Research led by the University of Michigan has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer's, Parkinson's and other neurodegenerative diseases.
3D tumor mapping reveals new insights into cancer biology and treatment
A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -; and the cells of a tumor's surrounding environment -; are organized, in 3D, and how that organization changes when a tumor spreads to other organs.
myeloMATCH program opens enrollment for acute myeloid leukemia and MDS
Four leading cancer research organizations in the United States and Canada announce the opening of patient enrollment to myeloMATCH, a unique portfolio of clinical trials to test precision medicine treatments for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
New antibody platform targets evolving viruses
Scientists at the Icahn School of Medicine at Mount Sinai, in collaboration with colleagues in the field, have developed an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2: their ability to mutate and evade existing vaccines and therapies.
Ancient DNA reveals insights into starch digestion
If you've ever struggled to reduce your carb intake, ancient DNA might be to blame. It has long been known that humans carry multiple copies of a gene that allows us to begin breaking down complex carbohydrate starch in the mouth, providing the first step in metabolizing starchy foods like bread and pasta.
New study reveals molecular mechanism in Alzheimer's disease
A research team at the Institute of Neurosciences of the University of Barcelona (UBneuro) has led a study describing a new molecular mechanism that affects RNA processing and alters the process of protein synthesis in the brains of Alzheimer's patients.
FDA strengthens AI regulation to ensure patient safety and innovation in healthcare
The FDA is adapting regulations to manage AI’s rapid development in healthcare, focusing on patient safety and the life cycle of AI tools. This review emphasizes the need for continuous monitoring to ensure AI performs effectively in clinical settings.
Two programs found to control invasion and inflammation in segregated tumor cell populations
Understanding in depth how tumors evolve to become malignant is the objective of the latest study led by the Cell Plasticity in Development and Disease laboratory, directed by ángela Nieto at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche.