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1. Cartagena, Colombia: The Most Beautiful City in South America Cartagena, Colombia is a city full of culture, history, and stunning architecture. Located on the Caribbean Sea, Cartagena has become one of the most popular tourist destinations in South America. From the colorful streets of the old town to the white-sand beaches and crystal-clear waters of the nearby islands, Cartagena has something for everyone. Whether you’re looking for an adventure-filled vacation or a relaxing getaway, Cartagena is the perfect destination. In this article, we’ll explore the top things to do in Cartagena and why it’s one of the most beautiful cities in South America. 2. Experience Cartagena's Historic Old Town No visit to Cartagena is complete without exploring the city’s historic old town. This UNESCO World Heritage Site is home to some of the city’s most impressive colonial-era architecture. Stroll through the narrow cobblestone streets and admire the colorful buildings, churches, and plazas. You’ll also find a number of museums, galleries, and cafes to explore. Be sure to visit the Castillo