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Kiran Mazumdar-Shaw talks about India’s battle with Covid-19 In an interview with DNA, Kiran Mazumdar-Shaw, Chairperson and Managing Director, Biocon, talks about India’s battle with Covid-19 and how the country is faring with its vaccination program. She also discusses the need for more investment in the healthcare sector, the development of the biotechnology industry and the importance of innovation in tackling the pandemic. She emphasizes the need for collaboration between industry, government and civil society to effectively tackle the pandemic.
All living things have a blueprint provided by the DNA that is stored in every one of their cells. Yet the amount of DNA in each cell—what we refer to as genome size—spans an incredible range across the tree of life.
We uncovered a potential role for chromosome rearrangements (i.e., fusions) of small monocentric chromosomes and the expansion of satellite DNA repeats interacting with CENH3 in a multistep transition to holocentricity in the woodrush species Luzula sylvatica.
A new study presents "Evo" – a machine learning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Evo's ability to predict, generate, and engineer entire genomic sequences could change the way synthetic biology is done.
Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers from The University of Texas at Austin and the University of California, Los Angeles has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history. The study was published last week in the journal Nature Communications.
Valine specifically binds to the primate-specific SE14 repeat domain of HDAC6, retaining it in the cytoplasm. Valine deprivation triggers HDAC6 nuclear shift, increasing DNA demethylation and damage via TET2 activation. Valine restriction inhibits tumor growth, and enhances the effects of PARPis.
Research published in Nature Ecology & Evolution introduces a novel method for inferring DNA methylation patterns in non-skeletal tissues from ancient specimens, providing new insights into human evolution. As DNA methylation is a key marker of gene expression, this work allows scientists to explore changes in gene activity in the brain and other tissues that are typically absent from the fossil record.