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The following are some of the news articles, videos, and other resources related to patient health and wellbeing. 1. Five Ways to Help Your Patients Heal Faster After Surgery: Advice from an Experienced Surgeon 2. The Benefits of Telemedicine: How Technology Is Improving Access to Quality Care 3. Mental Health: Understanding the Behavioral Health Crisis in America 4. How to Choose the Right Healthcare Provider for You 5. How to Manage Chronic Pain: Tips from an Expert 6. The Benefits of Mindfulness Meditation 7. 10 Tips for Eating Healthy on a Budget 8. The Benefits of Exercise for Overall Health 9. How to Talk to Your Doctor About Your Health 10. How to Handle Health Insurance Claims and Denials

Early stage gastric adenocarcinoma: clinical and molecular landscapes | Nature Reviews Clinical Oncology

Gastric adenocarcinoma, even when diagnosed at an early (localized) disease stage, poses a major health-care burden with cure rates that remain unsatisfactorily low, particularly in Western countries. This lack of progress reflects, among other aspects, the impracticality of early diagnosis, considerable variations in therapeutic approaches that is partly based on regional preferences, and the ingrained heterogeneity of gastric adenocarcinoma cells and their associated tumour microenvironment (TME). Clinical trials have long applied empirical interventions with the assumption that all early stage gastric adenocarcinomas are alike. Despite certain successes, the shortcomings of these approaches can potentially be overcome by targeting the specific molecular subsets of gastric adenocarcinomas identified by genomic and/or multi-omics analyses, including microsatellite instability-high, Epstein–Barr virus-induced, DNA damage repair-deficient, HER2-positive and PD-L1-high subtypes. Future approaches, including the availability of sophisticated vaccines, novel antibody technologies, agents targeting TME components (including fibroblasts, macrophages, cytokines or chemokines, and T cells) and novel immune checkpoint inhibitors, supported by improved tissue-based and blood-based diagnostic assays, seem promising. In this Review, we highlight current knowledge of the molecular and cellular biology of gastric adenocarcinomas, summarize the current approaches to clinical management of the disease, and consider the role of novel management and/or treatment strategies. Long-term survival rates of patients with gastric cancer remain low, particularly in Western countries. This lack of progress, among other aspects, is likely to reflect a focus on empirical approaches that fail to account for the heterogeneity of gastric cancers. In this Review, the authors summarize the available evidence on the management of patients with early stage gastric cancers, with an emphasis on understanding the underlying biology in order to improve the outcomes in patients with these historically difficult-to-treat tumours.