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The Cell Phone: A History The cell phone is one of the most revolutionary inventions of the modern era. Since the first commercially available cell phone was released in 1983, the device has changed the way we communicate and stay connected. From the first brick-sized mobile phones to today's sleek, pocket-sized versions, the cell phone has gone through numerous iterations over the past three decades. In this article, we take a look back at the history of the cell phone and the various milestones that have defined its evolution.
ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation | Research Communities by Springer Nature
The ICU patient-on-a-chip platform that we developed, is a sophisticated “living” model of the brain, allowing researchers to study complex interactions between drugs, brain cells and immune responses.
TSLPR CAR T-cell therapy: A new hope for CRLF2+ ALL, but timing of JAK inhibition is crucial | Research Communities by Springer Nature
Acute lymphoblastic leukemia (ALL) with CRLF2 rearrangements in Ph-like and Down syndrome-associated ALL subtypes poses a significant challenge in pediatric oncology. These genetic abnormalities lead to constitutive signaling activation and induce resistance to conventional chemotherapy.
Behind the Paper: How IL-6 shapes the anti-tumor battle and supports TGFβ immune modulatory vaccines in pancreatic cancer | Research Communities by Springer Nature
The study highlights that the antitumor efficacy of TGFβ-specific T cells in pancreatic cancer critically depends on IL-6 signaling. IL-6R blockade compromises the immune response by reducing vaccine-induced T-cell infiltration as well as increasing immunosuppressive tumor-associated macrophages.
The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base | Research Communities by Springer Nature
Emerging SARS-CoV-2 variants differ in infection dynamics, immune evasion, and pathogenicity. Our multi-omics study (https://www.nature.com/articles/s41421-024-00748-y) reveals how they manipulate host cells, uncovering variant-specific pathways and potential targets for intervention.
How calcium-regulated reprogramming primes legume root cells to welcome beneficial rhizobia symbionts | Research Communities by Springer Nature
Legumes host symbiotic nitrogen-fixing rhizobia within root nodules. To deliver rhizobia to nodules, the plant transiently creates cytoplasmic bridges to allow rhizobia entry and progression. Here we dissected the underlying extensive ultrastructural reprogramming and fine-tuned calcium regulation.