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The Cell Phone: A History The cell phone is one of the most revolutionary inventions of the modern era. Since the first commercially available cell phone was released in 1983, the device has changed the way we communicate and stay connected. From the first brick-sized mobile phones to today's sleek, pocket-sized versions, the cell phone has gone through numerous iterations over the past three decades. In this article, we take a look back at the history of the cell phone and the various milestones that have defined its evolution.
Patient-derived conditional reprogramming (CR) lets cells grow indefinitely, aiding in studying cancer, developing treatments, and advancing personalized medicine. This approach shows promise for improving urological cancer treatment.
aimed to address a challenge in CRISPR technology: ensuring control to avoid unintended edits. While CRISPR systems have revolutionized gene editing with remarkable accuracy, they can sometimes cause off-target effects due to their continuous activity, leading to cell damage or unexpected outcomes.
Alzheimer’s disease (AD) is widely known for its characteristic features, such as amyloid plaques and neurofibrillary tangles, but the role of different brain cell types in the progression of the disease is becoming increasingly important in research.
Simvastatin, a drug for heart disease by lowering cholesterol, also slows bladder cancer (BLCA) growth. It stops BLCA cells from multiplying by activating PPARγ, a fatty aicd/lipid metabolism pathway. This effect can be reversed with PPARγ inhibitors.
Also this week: analyzing biases in recommendation letters, against political endorsements by scientific journals, and more. From Jeremy: "For the first time, an open application process was used to attract applicants from a wide range of backgrounds. The Chancellor’s Election Committee has considered all applications solely on the specific exclusion criteria set out in the…
Pectolinarigenin (PEC) from herbal medicine targets DNA topoisomerase II alpha (TOP2A) in bladder cancer (BLCA), causing DNA damage and blocking cell division. It inhibits autophagy, boosting its effectiveness. Combined with gemcitabine, PEC more effectively halts BLCA growth.
Melatonin may help fight bladder cancer (BLCA) by slowing cancer cell energy production and increasing chemotherapy effectiveness, by targeting ENO1 to enhance gemcitabine’s impact and involving reactive oxygen species and PPARγ regulation. This suggests new methods for improving BLCA treatment.
CXCR6 is vital for maintaining CD8 tissue-resident memory (TRM) cells in the lungs. Our comparative genomic analysis of the CXCL16-CXCR6 axis shows variation in the DRF motif across vertebrates, with recurrent CXCR6 gene loss in 10 out of 36 bird orders, the crocodilians, and the elapid snakes.