Valine specifically binds to the primate-specific SE14 repeat domain of HDAC6, retaining it in the cytoplasm. Valine deprivation triggers HDAC6 nuclear shift, increasing DNA demethylation and damage via TET2 activation. Valine restriction inhibits tumor growth, and enhances the effects of PARPis.

Nature Ecology & Evolution Community

21.11.2024

Room calorimetry the new gold standard for RMR measurements | Research Communities by Springer Nature

For years the metabolic cart was considered the gold standard for measurement of resting metabolic rate. However, due to their inaccuracy and anxiety of people being placed under the ventilated hood, they are fast moving aside for the new gold standard in town...whole room indirect calorimetry.

Nature Ecology & Evolution Community

21.11.2024

Time for a syringe standing order: Important next step to assure syringe access to prevent HIV and hepatitis C. | Research Communities by Springer Nature

Reflections on pharmacy syringe sales for World AIDS Day 2024. A discussion of trends in syringe access and a call for state standing orders for syringes.

Nature Ecology & Evolution Community

21.11.2024

Does fire limit tropical tree cover? | Research Communities by Springer Nature

What happens when we remove fire from the tropics? Our study reveals the surprising impact fire has on tropical tree cover—and why it’s more complex than we thought.

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Human HDAC6 senses valine abundancy to regulate DNA damage | Research Communities by Springer Nature

Room calorimetry the new gold standard for RMR measurements | Research Communities by Springer Nature

Time for a syringe standing order: Important next step to assure syringe access to prevent HIV and hepatitis C. | Research Communities by Springer Nature

Does fire limit tropical tree cover? | Research Communities by Springer Nature

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