993 Epidermis-intrinsic N6-methyladenosine modification dampens skin inflammation - Journal of Investigative Dermatology
N6-methyladenosine (m6A) is the most prevalent internal modification of mRNA in eukaryotes,
and it is involved in various biological and pathological processes. Psoriasis and
atopic dermatitis (AD) are considered as common chronic inflammatory skin diseases,
and both of them feature epidermal acanthosis, hyperkeratosis, parakeratosis, infiltration
of immune cells as well as dermal changes. To reveal the effect of m6A in keratinocytes
(KCs), METTL3, a vital m6A methyltransferase, was specifically knockout in KCs of
adult mice, and spontaneous skin inflammation was observed, revealing that METTL3
might be essential for maintaining skin immune homeostasis.
