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A genetically attenuated malaria vaccine candidate with superior anti-malarial immunity | Research Communities by Springer Nature

A safe and effective vaccination strategy is needed to eradicate malaria. Late liver stage-arresting multiple gene knockout parasites are considered next-generation vaccines. Here, we developed a late liver-stage malaria vaccine candidate that provides superior antimalarial immunity.

Genetic legacy of Jomon hunter-gatherers linked to increased BMI in modern Japanese, study finds | ScienceDaily

New research exploring the roots of modern Japanese populations has linked the genetic signature of Jomon hunter-gatherers to a higher body mass index (BMI) among individuals, underlining that ancient human ancestors can leave a genetic legacy with impacts on health in modern day populations.

Q&A: Holobiont biology, a new concept for exploring how microbiome shapes evolution of visible life

Microorganisms—bacteria, viruses and other tiny life forms—may drive biological variation in visible life as much, if not more, than genetic mutations, creating new lineages and even new species of animals and plants, according to Seth Bordenstein, director of Penn State's One Health Microbiome Center, professor of biology and entomology, and the Dorothy Foehr Huck and J. Lloyd Huck Endowed Chair in Microbiome Sciences.

Genetic legacy of Jomon hunter-gatherers linked to increased BMI in modern Japanese populations

New research exploring the roots of modern Japanese populations has linked the genetic signature of Jomon hunter-gatherers to a higher body mass index (BMI) among individuals, underlining that ancient human ancestors can leave a genetic legacy with impacts on health in modern day populations.

The Genetic Book of the Dead by Richard Dawkins review – the great biologist’s swansong | Science and nature books | The Guardian

A wonderful but thoroughly conventional celebration of the science of evolution

Genes of ancient animal relatives used to grow a mouse: Study reveals hidden history of stem cells

An international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals.

Friday links: statistical inference vs. bridges, AI vs. time wasting, and more | Dynamic Ecology

Also this week: the phylogenetics of geometry, and more. Only a few links this week, but the average quality is higher than usual. Jessica Hullman points us to an old paper by Tukey and Cornfield on "the two spans of statistical inference." This is a very good metaphor for the role of statistics in solving…

Perturbation of the Silent Architects of Chemoresistance: The Epigenetic Dance of MYCNOS in Small Cell Lung Cancer | Research Communities by Springer Nature

Effect of genetically predicted sclerostin on cardiovascular biomarkers, risk factors, and disease outcomes | Research Communities by Springer Nature

Unveiling the Secrets of Longevity in India | Research Communities by Springer Nature

Mapmygenome's pioneering longevity study on Indians living over 85 reveals fascinating genetic secrets. Discoveries include variants linked to slower heart rate, short height, disease protection, and the FOX03A gene, offering valuable insights into longevity within the Indian population.