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Discover Latest #Serotonin News, Articles and Videos with Contenting
Serotonin is a neurotransmitter found in the brain that plays a role in many biological functions, including sleep, mood, and appetite. It is also believed to be involved in a variety of mental health conditions, including anxiety and depression. As such, serotonin has been the subject of much research and many news articles, videos, and other resources. Below are some of the most recent and informative articles, videos, and other resources related to serotonin and its role in mental health. 1. “What is Serotonin?” WebMD, webmd.com/mental-health/what-is-serotonin. This article provides an overview of serotonin and its functions in the body. It explains what serotonin does and how it affects mood and mental health. 2. “Serotonin and Depression” Harvard Health, health.harvard.edu/mind-and-mood/serotonin-and-depression. This article discusses the role of serotonin in depression and how medications and other treatments can affect serotonin levels. It provides an in-depth look at how serotonin affects mental health and how it can be used to treat depression. 3. “Serotonin and Anxiety
BU researcher receives $2.8M grant to study serotonin's role in chronic stress and depression
Michael Wallace, PhD, assistant professor of anatomy & neurobiology at Boston University Chobanian & Avedisian School of Medicine, was awarded a $2.8 million from the National Institutes of Health, National Institute of Mental Health.
Frontiers | Herbal medicine as adjunctive therapy with antidepressants for post-stroke depression: a systematic review and network meta-analysis of randomized controlled trials
Herbal medicine can provide adjunctive therapy for adults with post-stroke depression. This study summarizes the latest evidence regarding the harms and benefits of herbal antidepressants. Our search included the Cochrane Library (OVID platform), Embase, PubMed, China National Knowledge Infrastructure (CNKI), Wan Fang Data Knowledge Service Platform, and China Scientific Journal Database (VIP) from inception until December 1, 2022. The systematic review focused on randomized controlled trials of herbal medicine in adults with post-stroke depression. We conducted a frequentist random-effect network meta-analysis and utilized the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework to categorize interventions, rate the certainty of the evidence, and present our findings. Out of the 1132 citations that were identified during the search, this study included 51 randomized clinical trials with a total of 4507 participants. The results showed that Shugan Jieyu capsule (SJC) plus selective serotonin reuptake inhibitors (SSRI), Jie-Yu Pills plus SSRI, and Wuling capsule plus SSRI were among the most effective interventions for response rate, with moderate certainty of evidence (RR: 1.45, 95%CI: 1.23 to 1.7; RR: 1.35, 95%CI: 1.09 to 1.68; RR: 1.32, 95%CI: 1.09 to 1.59). In terms of reducing symptoms of depression, Wuling plus Hypericum and Wuling capsule plus SSRI were found to be the most effective with moderate certainty of evidence (MD: -10.12, 95%CI: -17.25 to -2.99; MD: -3.81, 95%CI: -6.19 to -1.42) based on mean changes in Hamilton depression scale (HAMD) score after treatment completion. The network meta-analysis (NMA) showed that SJC may be a safer intervention than SSRI in terms of both total gastrointestinal and total nervous system events with moderate certainty of evidence (RR:0.34, 95%CI:0.18, 0.62 and RR: 0.11, 95%CI: 0.03, 0.35, respectively) .Overall, SJC plus SSRI, Jie-Yu Pills plus SSRI, and Wuling capsule plus were the most effective interventions for reducing symptoms of depression. Furthermore, the study showed no increased risk of gastrointestinal and nervous system events with low to very low certainty of evidence .
Anxiety management in Australian general practice: an analysis of encounters from 2006 – 2016 | BMC Primary Care | Full Text
Anxiety disorders are highly prevalent mental health conditions managed predominantly by general practitioners (GPs). This study aimed to examine the management of anxiety by Australian GPs since the introduction of the Better Access to Psychiatrists, Psychologists and General Practitioners initiative in 2006. We conducted secondary analysis of Bettering the Evaluation and Care of Health data on GP encounters for anxiety from 2006 to 2016 (N = 28,784). We calculated point estimates and used multivariate logistic regression to explore the effect of GP and patient characteristics on rates and types of management. The management rate of anxiety increased from 2.3% of GP encounters in 2006 to 3.2% in 2016. Over the 10-year period, increases were seen in referrals to psychologists (AOR = 1.09, 95%CI = 1.07–1.11, p < .0001) and selective serotonin / serotonin-noradrenalin reuptake inhibitors (AOR = 1.05, 95%CI = 1.03–1.06, p < .0001), and benzodiazepines decreased (AOR = 0.94, 95%CI = 0.92–0.95, p < .0001). Systematic differences in management were found for patient and GP characteristics, including high rates of benzodiazepines in certain groups. Anxiety is accounting for more of the GP workload, year on year. GP management of anxiety has become more closely aligned with practice guidelines since 2006. However, high rates of benzodiazepine prescribing in certain groups remains a concern. Further research is needed into GP treatment decision making for anxiety.
A New Perspective on the Pathogenesis of Infantile Colic: Is... : Journal of Pediatric Gastroenterology and Nutrition
estionnaire was applied. Between the 6th and 8th postnatal weeks, day and night circadian histone gene H3f3b mRNA expression and spot urine excretion of serotonin, cortisol, and 6-sulphatoxymelatonin were analyzed. Results: Among the 95 infants included, 49 were diagnosed with infantile colic. In the colic group, defecation difficulty, sensitivity to light/sound, and maternal migraine frequency increased and sleep disruption was typical. In the melatonin analysis, the difference between day and night levels was significant in the control group, indicating an established circadian rhythm (P = 0.014). In the colic group, there was no day-night difference (P = 0.216) in melatonin, but serotonin levels were higher at night. In the cortisol analysis, day-night values were similar in both groups. Day-night variability of H3f3b mRNA levels between the groups was significant, indicating circadian rhythm disturbance in the colic group compared to the control group (P = 0.003). Fluctuations in circadian genes and hormones expected in healthy rhythm were revealed in the control group, but were missing in the colic group. Conclusion: Due to the gaps in the etipathogenesis in infantile colic, a unique effective agent has not been discovered so far. This study, which demonstrated for the first time that infantile colic is a biorhythm disorder using molecular methods, fills the gap in this regard and points to a completely different perspective in terms of treatment....